Altered Self, Altered World

Altered self, altered world.

Altered Receptors

Receptor disorders may produce specific clinical manifestations resembling hypo-or hyper-function of related endocrine gland. Receptor disorders can be divided into five categories: 1)Altered receptor concentration exists in insulin resistance seen in obsity, familial hypercholes­terolemia and in testicular feminization. 2) Altered receptor affinity can be seen in fasted obese patients, acromeg...

A clinical outcome comparison of the conventional altered cast impression with a modification altered cast impression technique

A clinical outcome comparison of the conventional altered cast impression with a modification altered cast impression technique Dr. M. Farzin *- Dr. F. Bahrani ** - Dr. A. Zareie *** *Assistant Professor of Prosthodontics Dept., Faculty of Dentistry, Shiraz University of Medical Sciences. **Clinical Instructor of Prosthodontics Dept., Faculty of Dentistry, Shiraz University of Medical Sciences....

Oxidative Stress, Altered-Self and Autoimmunity

It is well known that oxidative stress can induce production of free radicals that can modify proteins. The hypothesis presented here is that the target antigens in autoimmune diseases, such as type 1 diabetes mellitus, are not normal self proteins but rather self proteins that have been altered by free radicals, produced as a result of oxidative stress in the target cells. The observation that...

Cancer Antigens: Immune Recognition of Self and Altered Self By

A tacit assumption of cancer immunology has been that tumors express non-self or "foreign" antigens. The recent identification of a handful of potentially immunogenic cancer antigens shows that they are not truly foreign. Although the boundary between self and non-self is not well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than with the non-self para...